Peel and devein your shrimp if required. Roll in paper towels to ensure as dry as possible.
Preheat oven to 400 deg F.
Place flour, garlic powder, onion powder, paprika, salt, and pepper into wide bowl, pie pan, etc. Mix to combine.
Crack eggs and ½ cup water into wide bowl, pie pan, etc. Mix to combine.
Pour panko onto plate. Mix to combine?
Line two cookie sheets with aluminum foil. Spray with cooking spray.
Batter the shrimp: place dry shrimp into flour, shake off excess, then into egg wash, shake off excess, then into panko, gently pressing crumbs into the shrimp. Lay breaded shrimp onto sheet tray, being sure not to crowd. Let shrimp rest on tray for 10 minutes to ensure the panko has set. ***
Spray shrimp gently with cooking spray, then bake in over for ~20 minutes, flipping halfway. Remove and serve immediately (say with a chimichurri sauce to dip in).